You are correct. Please use 18.104.22.168 #67. That is the latest one where we added support for 4.0.30319.18052 (32+64). If you are not receiving any messages about unsupported frameworks in your BMC AppSight System Console (Summary tab) then there is no need to update the dninfo.nef file.
Remco, I had one of our clients install 22.214.171.124 #67, and am receiving a message that 2.0.50727.3649 is not supported. We received an updated dninfo.nef back in August 2013 that did include this version. Is 2.0.50727.3649 not included in the latest dninfo.nef?