what do you mean 'withstand a sysprep image' ? and what part of blaldelogic are you referring to ?
My guess is that you're asking if you can embed the RSCD agent into a sysprep image and if it needs a unique GUID to function?
If so, the only issue I foresee would be that you would need to license the agent as soon as the server is imaged in order for the agent to function. I don't think you have to worry about GUIDs.