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You can not customize My settings .
You can switch to old interface so that you can customize the user page layout and assign to profiles but still it will not give you lot of flexibility.
User user interface > you can uncheck "Enable Improved Setup User Interface"
You can also simply add a validation rule on user object say
NOT($Profile.Name="System Administrator") message - only administrator can make changes.
so that only administrator can change any information.
Thanks, I will try the validation rule.
The validation rule is a good work around; I like that this is just restricting the user object parts of the settings and other areas I don't care if they are altered can still function. I love the look of the 'Enable Improved Setup User Interface' though it seems like there should be profile based viewing restrictions that can be placed on parts of it perhaps by section.